1478:

Pazzi Conspiracy fails

In an attempt to overthrow the Medici family from power in Florence, Girolamo Riario, Archbishop Francesco Salviati, and several members of the Pazzi family planned an assassination in the Cathedral of Florence. Pope Sixtus IV, uncle to Riario, was aware of the plot but had no hand in the assassination attempt.

Lorenzo de Medici survived with some minor injuries, but his younger brother Giuliano was stabbed 29 times. He was only twenty-three. Far from ridding Florence of "tyrants," the assassination instigated an uprising in favor of the Medici, strengthening Lorenzo's position.